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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T83729 Tat-CIRP TFA

Tat-Cold-inducible RNA Binding Protein

Tat-CIRP是一种肽类抑制剂,用于抑制髓样分化2蛋白(MD-2,亦称淋巴细胞抗原96 [LY96])与寒冷诱导的RNA结合蛋白(CIRP)之间的蛋白-蛋白相互作用。它通过与MD-2结合,干扰MD-2与CIRP之间的相互作用,这一作用在共免疫沉淀实验中得到证实。在体内实验中,Tat-CIRP (10及20 mg/kg) 能够减少由中脑动脉闭塞(MCAO)引发的小鼠脑梗死体积。同样,在通过血栓引发脑梗死的恒河猴模型中,Tat-CIRP同样能减少脑梗死体积,并缩短患中风一侧手臂抓取并放下食物的时间。

化合物

Tat-CIRP TFA
Cat.No: T83729
Synonym: Tat-Cold-inducible RNA Binding Protein
Target:
Cat. No. Product Name Species Expression System
TMPK-01242 MD2/LY96 Protein, Human, Recombinant (His)

MD-2,Ly-96,ESOP-1,Lymphocyte antigen

Human E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1.
TMPY-03999 MD2/LY96 Protein, Mouse, Recombinant (hFc)

lymphocyte antigen 96,ESOP-1,MD2,...

Mouse HEK293 Cells
LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa...
TMPK-00632 MD2/LY96 Protein, Cynomolgus, Recombinant (His)

ESOP-1,LY96,Lymphocyte antigen

Cynomolgus E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0.

重组蛋白

MD2/LY96 Protein, Human, Recombinant (His)
Cat.No: TMPK-01242
Species: Human
Expression System: E. coli
MD2/LY96 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03999
Species: Mouse
Expression System: HEK293 Cells
MD2/LY96 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00632
Species: Cynomolgus
Expression System: E. coli
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